After pointing out the great influence of this philosophical system, Mr. Morrison looser no time in going to the heart of it. He is will qualified forth is study, having spent much time in reading and discussion concerning ths great proponents of the system.

We discuss our surgical philosophy concerning the subtle interplay between the size of the surgical margin taken and the resultant morbidity from ablative oncological. procedures, which is ever more evident in the treatment of head and neck malignancy. The extent of tissue resection is determined by the "trade off" between cancer control and the perioperative, functional and aesthetic morbidity and mortality of the surgery. We also discuss our dilemmas concerning recent minimally invasive endoscopic microsurgical. techniques for the trans-oral laser removal. (...) or co-ablation of aero-digestive tract tumours, which result in a minimal. surgical margin of oncological clearance. By a process of inductive argument as to the nature of the surgical margin, we consider whether the risks of taking a lesser margin with adjuvant therapy is justified by the attendant gain in reduced surgical morbidity and the possible costs in tumour control. (c) 2006 Elsevier Ltd. All rights reserved. (shrink)

A letter from Howard C. Berkowitz about “Impact of a Clinical Trials Information Handbook on Patient Knowledge, Perceptions, and Likelihood of Participation”.

The Institutional Animal Care and Use Committee is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity (...) to the IACUC without mandating a particular outcome. To do this, we analyze the underlying logic of the Three Rs and conclude that the Three Rs accord animals moral standing, though not necessarily “rights” in the philosophical sense. We suggest that the Rs are hierarchical, such that Replacement, which can totally eliminate harm, should be considered prior to Reduction, which decreases the number of animals harmed, with Refinement being considered last. We also identify the need for a hitherto implicit fourth R: Reject, which allows the IACUC to refuse permission for a project which does not promise sufficient benefit to offset the pain and distress likely to be caused by the proposed research. (shrink)

The physics and metaphysics of identity and individuality Content Type Journal Article DOI 10.1007/s11016-010-9463-7 Authors Don Howard, Department of Philosophy and Graduate Program in History and Philosophy of Science, University of Notre Dame, Notre Dame, IN 46556, USA Bas C. van Fraassen, Philosophy Department, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, USA Otávio Bueno, Department of Philosophy, University of Miami, Coral Gables, FL 33124, USA Elena Castellani, Department of Philosophy, University of Florence, Via Bolognese 52, (...) 50139 Florence, Italy Laura Crosilla, Department of Pure Mathematics, School of Mathematics, University of Leeds, Leeds, LS2 9JT UK Steven French, Department of Philosophy, University of Leeds, Leeds, UK Décio Krause, Department of Philosophy, Federal University of Santa Catarina, 88040-900 Campus Trindade, Florianópolis, SC Brazil Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796. (shrink)